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Search Results for " monoamine transporter "

25

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7147	Valbenazine NBI-98854	Monoamine Transporter	Membrane transporter/Ion channel
	Valbenazine (NBI-98854) 是一种高度选择性的囊泡单胺转运蛋白 2 (VMAT2) 抑制剂，Ki 为 110-190 nM，用于治疗迟发性运动障碍。
T22714	Decynium 22	Others	Others
	Decynium 22 是有机阳离子转运蛋白和单胺转运蛋白的抑制剂，具有抗抑郁作用。
T23070	Nisoxetine hydrochloride	Sodium Channel; Monoamine Transporter; Norepinephrine	Membrane transporter/Ion channel; Neuroscience
	Nisoxetine hydrochloride 是一种去甲肾上腺素转运蛋白 (NET) 抑制剂，Kd 值为 0.76 nM。它是抗抑郁药和局部麻药，可以阻断电压门控性钠通道。
T1993	J-147 J147	Epigenetic Reader Domain; Dopamine Receptor; Monoamine Oxidase	Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
	J-147 是一种高效的、具有口服活性的、可透过血脑屏障神经保护剂，可增强认知能力。它抑制单胺氧化酶 B 和多巴胺转运体，EC50分别为 1.88 μM 和 0.649 μM。它有研究阿尔茨海默氏症的潜力。
T0719	Tetrabenazine Xenazine,丁苯那嗪,Ro 1-9569	Others; Dopamine Receptor; Monoamine Transporter	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience; Others
	Tetrabenazine (Ro 1-9569) 是 VMAT 抑制剂，用作抗精神病药和治疗各种运动障碍。
T3534	Tetrabenazine Racemate Nitoman,丁苯那嗪外消旋体,丁苯那嗪,Ro 1-9569 Racemate,Rubigen,TETRABENAZINE	Monoamine Transporter	Membrane transporter/Ion channel
	Tetrabenazine Racemate (Rubigen) 是一种选择性和可逆的囊泡单胺转运蛋白 2(VMAT-2) 抑制剂。它阻断神经递质吸收到肾上腺素能储存囊泡中，并已被用作囊泡运输系统的高亲和力标记。
T7563	NBI-98782 (+)-α-二氢丁苯那嗪,(+)-α-Dihydrotetrabenazine,(+)-α-DHTBZ,(+)-DTBZ,[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-六氢-9,10-二甲氧基-3-异丁基-2H-苯并[a]喹嗪-2-醇	Monoamine Transporter	Membrane transporter/Ion channel
	NBI-98782 ((+)-α-DHTBZ) 是一种囊泡单胺转运蛋白 (VMAT2) 抑制剂，Ki 为0.97nM。
T13134	(+)-Tetrabenazine (+)-TBZ,(3R,11bR)-Tetrabenazine,(3R,11bR)-TBZ	Monoamine Transporter	Membrane transporter/Ion channel
	(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) 是一种可逆的囊泡单胺转运蛋白2 (VMAT-2)抑制剂，对 VMAT2转运的抑制作用是VMAT1的10倍。
T7651	Rose Bengal sodium Rose Bengal,酸性红 94	Influenza Virus; Monoamine Transporter	Membrane transporter/Ion channel; Microbiology/Virology
	Rose Bengal sodium 是一种合成的荧光素衍生物，主要成分是 4,5,6,7-tetrachloro-2,4,5,7-tetraiodo 荧光素，可以检测眼表干燥或受损的细胞，用作眼科诊断剂，具有抗病毒活性。它是一种 VGlut 和囊泡单胺转运蛋白抑制剂，VGlut 和 VMAT 的 Ki 分别为 19 和 64 nM。
T13133	Tetrabenazine Metabolite (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ	Monoamine Transporter	Membrane transporter/Ion channel
	Tetrabenazine Metabolite ((-)-β-HTBZ) 是一种囊泡单胺转运蛋白 2 (VMAT2) 抑制剂，是 Tetrabenazine 的一种活性代谢物。Tetrabenazine Metabolite 对 VMAT2 具有高亲和力，其Ki 为13.4 nM。Tetrabenazine Metabolite 常常被用于研究与亨廷顿氏病和其他多动障碍相关的舞蹈病。
T22781L	FFN 511 hydrochloride FFN 511 hydrochloride(1004548-96-2 Free base)
	FFN 511 hydrochloride 是一种针对神经元囊泡单胺转运体 2 (VMA T2) 的荧光假神经递质 (FFNs)。FFN 511 hydrochloride 可抑制 5-羟色胺与含 VMA T2 的膜结合，可用于标记活体皮质-纹状体急性切片中的多巴胺能神经末梢。激发和发射最大值分别为 406 和 501 nm。
T31790	FFN200 dihydrochloride FFN200 HCl,FFN200,FFN 200,FFN-200
	FFN200 is a vesicular monoamine transporter 2 (VMAT2) substrate that selectively traces monoamine exocytosis in both neuronal cell culture and brain tissue.
T68488	Indatraline
	Indatraline is a nonselective monoamine transporter inhibitor.
T25750	Lobelane Hydrochloride
	Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.
T31791	FFN246 HCl FFN 246,FFN246 hydrochloride,FFN246,FFN-246
	FFN246 is a fluorescent substrate for both the serotonin transporter and the vesicular monoamine transporter 2 (VMAT2).
T70322	Valbenazine dihydrochloride
	Valbenazine dihydrochloride inhibits vesicular monoamine transporter 2 (VMAT2); used to treat tardive dyskinesia.
T23629	Adam I-123 Adam I 123,Adam I123
	Adam I-123 is a radiopharmaceutical containing the serotonin transporter (SERT) ligand, with SERT-binding and radioisotope activities. SERT is a monoamine transporter protein found in the membranes of neurons and platelets.
T24941	VMAT2-IN-I HCl VMAT2 IN I Hydrochloride,VMAT2-IN-I Hydrochloride,VMAT2INI Hydrochloride
	VMAT2-IN-I HCl is an inhibitor of vesicular monoamine transporter-2. It also has 15- fold greater affinity than GZ- 793A.
T36949	Niaprazine	5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Niaprazine 是有效的组胺 H1 受体拮抗剂，具有抗组胺和抗血清素活性。Niaprazine 在睡眠障碍方面有研究的价值。
T27689	JNJ-7925476 HCl JNJ-7925476,JNJ7925476,JNJ 7925476
	JNJ-7925476 HCl is a triple monoamine uptake inhibitor. JNJ-7925476 Salt blocks the dopamine transporter (DAT), norepinephrine transporter (NET) and serotonin transporter (SERT) in the central nervous system. The ED(50) values for JNJ-7925476 occupancy of
T12190	Trans (2,3)-Dihydrotetrabenazine (2R,3R,11bR)-rel-DHTBZ,(2R,3R,11bR)-rel-Dihydrotetrabenazine	Others	Others
	Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).
T22452	Valbenazine tosylate 結苯那嗪,NBI-98854	Monoamine Transporter	Membrane transporter/Ion channel
	Valbenazine tosylate, the tosylate salt of valbenazine, is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no significant binding to VAMT1(Ki<10 μM).
T9300	DiPT
	DiPT 是5HT2A 受体的激动剂和5HT1A 受体的部分激动剂, 抑制 5-羟色胺转运体和泡状单胺转运体 2 的转运。
T78684	FFN246	5-HT Receptor	GPCR/G Protein; Neuroscience
	FFN246作为serotonin transporter (SERT) 和 vesicular monoamine transporter2 (VMAT2) 的荧光双底物探针，具有392/427 nm的激发和发射光谱。该化合物能够通过SERT依赖性积累，标记小鼠脑组织中的5-羟色胺能神经元。
T71772	Bicifadine free base
	Bicifadine, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs. While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad...

化合物

Cat.No: T7147

Synonym: NBI-98854

Target: Monoamine Transporter

Cat.No: T22714

Target: Others

Nisoxetine hydrochloride

Cat.No: T23070

Target: Sodium Channel, Monoamine Transporter, Norepinephrine

Cat.No: T1993

Synonym: J147

Target: Epigenetic Reader Domain, Dopamine Receptor, Monoamine Oxidase

Cat.No: T0719

Synonym: Xenazine,丁苯那嗪,Ro 1-9569

Target: Others, Dopamine Receptor, Monoamine Transporter

Tetrabenazine Racemate

Cat.No: T3534

Synonym: Nitoman,丁苯那嗪外消旋体,丁苯那嗪,Ro 1-9569 Racemate,Rubigen,TETRABENAZINE

Target: Monoamine Transporter

Cat.No: T7563

Synonym: (+)-α-二氢丁苯那嗪,(+)-α-Dihydrotetrabenazine,(+)-α-DHTBZ,(+)-DTBZ,[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-六氢-9,10-二甲氧基-3-异丁基-2H-苯并[a]喹嗪-2-醇

Target: Monoamine Transporter

(+)-Tetrabenazine

Cat.No: T13134

Synonym: (+)-TBZ,(3R,11bR)-Tetrabenazine,(3R,11bR)-TBZ

Target: Monoamine Transporter

Rose Bengal sodium

Cat.No: T7651

Synonym: Rose Bengal,酸性红 94

Target: Influenza Virus, Monoamine Transporter

Tetrabenazine Metabolite

Cat.No: T13133

Synonym: (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ

Target: Monoamine Transporter

FFN 511 hydrochloride

Cat.No: T22781L

Synonym: FFN 511 hydrochloride(1004548-96-2 Free base)

FFN200 dihydrochloride

Cat.No: T31790

Synonym: FFN200 HCl,FFN200,FFN 200,FFN-200

Cat.No: T68488

Lobelane Hydrochloride

Cat.No: T25750

Cat.No: T31791

Synonym: FFN 246,FFN246 hydrochloride,FFN246,FFN-246

Valbenazine dihydrochloride

Cat.No: T70322

Cat.No: T23629

Synonym: Adam I 123,Adam I123

Cat.No: T24941

Synonym: VMAT2 IN I Hydrochloride,VMAT2-IN-I Hydrochloride,VMAT2INI Hydrochloride

Cat.No: T36949

Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

JNJ-7925476 HCl

Cat.No: T27689

Synonym: JNJ-7925476,JNJ7925476,JNJ 7925476

Trans (2,3)-Dihydrotetrabenazine

Cat.No: T12190

Synonym: (2R,3R,11bR)-rel-DHTBZ,(2R,3R,11bR)-rel-Dihydrotetrabenazine

Target: Others

Valbenazine tosylate

Cat.No: T22452

Synonym: 結苯那嗪,NBI-98854

Target: Monoamine Transporter

Cat.No: T9300

Cat.No: T78684

Target: 5-HT Receptor

Bicifadine free base

Cat.No: T71772

Cat. No.	Product Name	Target	Signaling Pathways
T0791	Reserpine 利血平,Serpalan,Serpasil,Serpivite	Others; Potassium Channel; MRP; Monoamine Transporter; Autophagy	Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Others
	Reserpine (Serpalan) 是一种从催吐萝芙木的根中发现的生物碱。它抑制去甲肾上腺素吸收到储存囊泡中，导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽。它可作为抗高血压药和抗精神病药以及研究工具。
T3933	Jatrorrhizine Yatrorizine,neprotin,药根碱	MAO; 5-HT Receptor; Antibacterial; AChE	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Jatrorrhizine (neprotin) 是一种从黄连中分离得到的生物碱，具有抗菌、抗氧化、抗疟原虫和神经保护活性。它通过抑制 uptake-2 transporter 的活性减少血清素和去甲肾上腺素的摄取。它是一种有口服活性的乙酰胆碱酯酶制剂。

天然产物

Cat.No: T0791

Synonym: 利血平,Serpalan,Serpasil,Serpivite

Target: Others, Potassium Channel, MRP, Monoamine Transporter, Autophagy

Cat.No: T3933

Synonym: Yatrorizine,neprotin,药根碱

Target: MAO, 5-HT Receptor, Antibacterial, AChE

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